My antivirus solution of choice is Microsoft Security Essentials because it is free, lightweight and scores highly in virus and malware detection in many independent reviews.
Unfortunately it doesn't play nice with Windows Home Server and every time I boot my machine I receive an alert stating that there is no spyware detection. Although the alert clears automatically after a minute or so it is still annoying as I have my server configured to also send email alerts.
However, there is a very simple solution to this problem. Simply bring up Control Panel, navigate to Services and then change the properties of the Security Center service from "Automatic (Delayed start)" to "Automatic".
Note: I have since discovered that this behaviour occurs with other antivirus and security suites, not just Microsoft Security Essentials.